Publications

  1. Fiolek, Taylor J.; Keel, Katarina L. and Tepe, Jetze J. Fluspirilene analogs activate the 20S proteasome and overcome proteasome impairment by intrinsically disorder protein oligomers, 2020, submitted.
  2. Hubbell, Grace E. and Tepe, Jetze J. Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors, RSC Chemical Biology 2020, in press.
  3. Keel, Katarina L. and Tepe, Jetze J. The preparation of (4H)-imidazol-4-ones and their application in the total synthesis of natural products, Organic Chemistry Frontiers 2020, in press. https://doi.org/10.1039/D0QO00764A
  4. Mehedi, Md Shafaat Al and Tepe, Jetze J.Recent Advances in the Synthesis of Imidazolines (2009-2020)", Adv. Synth. Catal. 2020, in press. https://doi:10.1002/adsc.202000709
  5. Njomen, Evert; Lansdell, Theresa A.; Benham, Vanessa; Bernard, Matt P.; Yang, Ya-Ting; Schall, Peter Z.; Isaac, Daniel; Omar Alkharabsheh; Al-Janadi Anas;Giletto, Matthew B.; Ellsworth, Edmund; Taylor, Catherine; Tang, Terence; Lau, Sarah; Bailie, Marc, Bernard; Jamie J.; Yuzbasiyan-Gurkan, Vilma and Tepe, Jetze J., 20S proteasome enhancement targets c-MYC and induces in vivo anti-tumor efficacy, BioRxiv, 2020, https://doi.org/10.1101/2020.08.24.265470
  6. Mehedi, Md Shafaat Al and Tepe, Jetze J.Recent Advances in the Synthesis of Imidazolines (2009-2020)", Adv. Synth. Catal. 2020, in press. DOI:10.1002/adsc.202000709.
  7. Mehedi, Md Shafaat Al and Tepe, Jetze J. Sc(OTf)3 mediated one pot synthesis of 2,3-disubstituted quinolines from anilines and epoxides, J. Org. Chem. 2020, 85, 6741-6746. DOI:10.1021/acs.joc.0c00803

    Sc(OTf)3 mediated one pot synthesis of 2,3-disubstituted quinolines from anilines and epoxides

  8.  Article highlighted in Synfacts 2020; 16(08): 0898. DOI: 10.1055/s-0040-1706834
  9. Njomen, Evert; Lansdell, Theresa A.; Vanecek, Allison, Benham, V. ; Krieger-Burke, Teresa; Bernard, Matthew; Yang Ya-Ting; Alkharabsheh, Omar; Al-Janadi, Anas; Bailie, Marc; Taylor, Catherine; Lau, Sarah; Bernard, Jamie; Yuzbasiayan-Gurkan, V. and Tepe, Jetze J. 20S Proteasome enhancement targets the intrinsically disordered c-MYC and induces in vivo anti-tumor efficacy, 2020, submitted.
  10. Jones, Corey and Tepe, Jetze J. Proteasome Activation to Combat Proteotoxicity, Molecules, 2019, 24, 2841. PMID 31387243  DOI: 10.3390/molecules24152841
    1. Special Issue: Proteasome Regulators: Activators and Inhibitors
  11. Njomen, Evert and Tepe, Jetze J. Regulation of Autophagic Flux by the 20S proteasome. Cell, Chemical Biology, 2019, 26, 1283-1294. PMID31327703 DOI: 10.1016/j.chembiol.2019.07.002
  12. Njomen, Evert and Tepe, Jetze J. Proteasome activation as a new therapeutic approach to target proteotoxic disorders, Journal of Medicinal Chemistry, 2019, 62, 6469-6481. PMID: 30839208. DOI: 10.1021/acs.jmedchem.9b00101
    1. Article recommended by F1000Prime

    Proteasome activation as a new therapeutic approach to target proteotoxic disorders

  13. Mehedi, Md Shafaat Al and Tepe, Jetze J. Diastereoselective one-pot synthesis of oxazolines using sulfur ylides and acyl imines, Journal of Organic Chemistry, 2019, 84, 7219-7226. PMID: 31117573. DOI: 10.1021/acs.joc.9b00883

    Diastereoselective one-pot synthesis of oxazolines using sulfur ylides and acyl imines

  14. Giletto, Matthew B; Osmulski, Pawel A.; Jones, Corey L.; Gaczynska Marie E. and Tepe, Jetze J. Pipecolic esters as new templates for proteasome inhibition, Organic & Biomolecular Chemistry, 2019, 17, 2734-2746. PMID: 30778435. DOI: 10.1039/c9ob00122k
  15. Gao, Shuang, Bethel, Travis K. Kakeshpour T.; Hubbell, Grace E., Jackson, James, E. and Tepe, Jetze J. Substrate Controlled Regioselective Bromination of 2-Aycl Pyrroles Using Tetrabutyl Ammonium Tribromide (TBABr3), Journal of Organic Chemistry, 2018, 83, 9250-9255. PMID: 29969032. DOI: 10.1021/acs.joc.8b01251

    Substrate Controlled Regioselective Bromination of 2-Aycl Pyrroles Using Tetrabutyl Ammonium Tribromide (TBABr3)

  16. Njomen, Evert; Osmulski, Pawel A.; Jones, Corey L; Lansdell, Theresa A. Gaczynska, Maria E. and Tepe, Jetze J. Small Molecule Modulation of Proteasome Assembly, Biochemistry 2018, 57,4214-4224. PMID: 29897236. DOI: 10.1021/acs.biochem.8b00579
    1. Article recommended by F1000Prime

    Small Molecule Modulation of Proteasome Assembly

  17. Jones, Corey L.; Njomen, Evert; Sjogren B.; Dexheimer, Thomas S. and Tepe, Jetze J. Small molecule enhancement of 20S proteasome activity targets intrinsically disordered proteins, ACS Chemical Biology 2017, 15, 2240-2247. PMID: 28719185. DOI: 10.1021/acschembio.7b00489

    Small molecule enhancement of 20S proteasome activity targets intrinsically disordered proteins

  18. McDaniel, Tanner J.; Lansdell, Theresa A.; Dissanayake, Amila A.; Azevedo, Lauren M.; Claes, Jacob; Odom, Aaron L. and Tepe, Jetze J. Substituted quinolines as noncovalent proteasome inhibitors, Bioorganic and Medicinal Chemistry, 2016, 24, 2441-2450. PMID: 27112450. DOI: 10.1016/j.bmc.2016.04.005

    Substituted quinolines as noncovalent proteasome inhibitor

  19. Zaib, Rahman S. and Tepe, Jetze J. A concise total synthesis of hymenialdisine, Tetrahedron Letters, 2015, 56, 3011-3013. DOI: 10.1016/j.tetlet.2014.10.022
    1. Article selected for: Special Issue dedicated to Prof. H. Wasserman.

    A concise total synthesis of hymenialdisine

  20. Kuszpit, Michael R.; Giletto, Matthew B.; Jones, Corey L.; Bethel, Travis K. and Tepe, Jetze J. Hydroxyamination of olefins using Br-N-(CO2Me)2. Journal of Organic Chemistry, 2015, 80, 1440-1445. PMID: 25574949. DOI: 10.1021/jo502369d

    Hydroxyamination of olefins using Br-N-(CO2Me)2

  21. Beck, Philipp; Lansdell, Theresa A.; Hewlett, Nicole M.; Tepe, Jetze J. and Groll, Michael. Indolo-phakellins as b5-specific noncovalent proteasome inhibitors, Angewandte Chemie International Edition, 2015, 54, 2830-2833. PMID: 25581903. DOI: 10.1002/anie.201410168
    1. Article highlighted by editors as: Hot Paper.
  22. Basson, Marc D.; Zeng B; Downey C; Siriveluprabhakara S, Tepe, Jetze J. Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-b, Molecular Oncology, 2015, 9, 513-526. PMC: 4487881. DOI: 10.1016/j.molonc.2014.10.008
  23. Hewlett, Nicole M. and Tepe, Jetze J. 2-Phenyl oxazolone, Electronic Encyclopedia of Reagents for Organic Synthesis, 2014, 1-3. DOI: 10.1002/047084289X.rn01743
  24. Azevedo, Lauren M.; Lansdell, Theresa A.; Ludwig, Jacob R.; Mosey, R. Adam; Woloch, Daljinder K.; Cogan, Dillon P.; Patten, Gregory P.; Kuszpit, Michael R.; Fisk, Jason S. and Tepe, Jetze J. Inhibition of the human proteasome by imidazoline scaffolds, Journal of Medicinal Chemistry, 2013, 56, 5974-5978. PMC: 3844044. DOI: 10.1021/jm400235r
    1. Article Highlighted in Science Business Exchange SciBX 6(28), July 25, 2013

    Inhibition of the human proteasome by imidazoline scaffolds

  25. Lansdell, Theresa A.; Hurchla, Michelle A.; Xiang, J.; Hovde, S.; Weilbaecher, Katherine N.; Henry, R. William; Tepe, Jetze J. Noncompetitive modulation of the proteasome by imidazoline scaffolds overcomes bortezomib resistance and delays MM tumor growth in vivo, ACS Chemical Biology, 2013, 8, 578-587. PMC: 3600058. DOI: 10.1021/cb300568r
    1. Article Highlighted: ACS Chemical Biology editors highlight article from Volume 8, Issue 3 and speak with author Jetze Tepe on itunes podcast, March 2013.
    2. Article recommended by F1000Prime

    Noncompetitive modulation of the proteasome by imidazoline scaffolds overcomes bortezomib resistance and delays MM tumor growth in vivo

  26. Nguyen, Thu N.T.; Saleem, Rahman S. Z.; Luderer, Micah, J.; Tepe, Jetze J. Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors, ACS Chemical Biology, 2012, 7, 172-184. PMID: 22004065. DOI: 10.1021/cb200320c

    Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors

  27. Lansdell, Theresa A.; O'Reilly, Sandra; Woolliscroft, Tracey; Azevedo, Lauren M.; Kahlon, Daljinder K.; Hovde, Stacy; McCormick, J. Justin; Henry, R. William; Cornicelli, Joseph A.; Tepe, Jetze J. Non-competitive inhibition of the human proteasome attenuates collagen-induced arthritis, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 4816-4819.  PMID: 22682057. DOI: 10.1016/j.bmcl.2012.05.056

    Non-competitive inhibition of the human proteasome attenuates collagen-induced arthritis

  28. Lansdell, Theresa A.; Hewlett, Nicole M.; Skoumbourdis, Amanda P.; Fodor, Matthew D.; Seiple, Ian B.; Su, Shun; Baran, Phil. S.; Feldman, Ken S.; Tepe, Jetze J. Palau’amine and Related Oroidin-alkaloids Dibromophakellin and Dibromophakellstatin Inhibit the Human 20S Proteasome. Journal of Natural Products, 2012, 75, 980-985.  PMC: 3367325. DOI: 10.1021/np300231f
    1. Article recommended by F1000Prime, 17 Jul 2018; F1000Prime.com/717748071

    Palau’amine and Related Oroidin-alkaloids Dibromophakellin and Dibromophakellstatin Inhibit the Human 20S Proteasome

  29. Saleem, Rahman Shah Zaib; Lansdell, Theresa A.; Tepe, Jetze J. Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors, Bioorganic & Medicinal Chemistry, 2012, 20, 1475-1481. PMID: 20481587. DOI: 10.1016/j.bmc.2011.12.054

    Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors

  30. Hewlett, Nicole M.; Tepe, Jetze J. Total synthesis of the natural product (±)-dibromophakellin and analogues, Organic Letters, 2011, 13, 4550-4553. PMC: 3162990. DOI: 10.1021/ol201741r

    Total synthesis of the natural product (±)-dibromophakellin and analogues

  31. Nguyen, T. N. T.; Tepe, Jetze J. Checkpoint kinase inhibitors. Current Medicinal Chemistry, 2011, 18, 4368-4374. DOI: 10.2174/092986711797200390
  32. Qu, Ke; Fisk, Jason S.; Tepe, Jetze J. Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolines, Tetrahedron Letters, 2011, 52, 4840-4842. PMC: 3157035. DOI: 10.1016/j.tetlet.2011.07.022

    Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolines

  33. Frawley Cass, Samantha M.; Tepe, Jetze J.  Identification of phosphoproteins and their impact as biomarkers in cancer therapeutics,   Current Signal Transduction Therapy, 2011, 6, 113-140. DOI: 10.2174/157436211794109389
  34. Kuszpit, Michael R.; Wulff, William D.; Tepe, Jetze J. One-Pot Synthesis of 2-Imidazolines via the Ring Expansion of Imidoyl Chlorides with Aziridines,  Journal of Organic Chemistry, 2011, 76, 2913-2919. PMC: 3074022. DOI: 10.1021/jo200101q

    One-Pot Synthesis of 2-Imidazolines via the Ring Expansion of Imidoyl Chlorides with Aziridines

  35. Saleem, Rahman Shah Zaib; Tepe, Jetze J. Synthesis of 1,2,4-triazolines and triazoles utilizing oxazolones,  Journal of Organic Chemistry, 2010, 75, 4330-4332. DOI: 10.1021/jo100716m
    1. Article highlighted in Synfacts 2010, 0997.

    Synthesis of 1,2,4-triazolines and triazoles utilizing oxazolones

    1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride-Mediated Oxazole Rearrangement: Gaining Access to a Unique Marine Alkaloid Scaffold

  36. Tepe, Jetze J. Recent advances in cycloaddition reactions in natural product synthesis, Current Organic Synthesis, 2010,7, 311. DOI: 10.2174/157017910791414481
  37. Wang, Wei-Han; Palumbo, Amanda M.; Tan, Yu-Jing; Reid, Gavin E.; Tepe, Jetze J.; Bruening, Merlin L. Identification of p65-Associated Phosphoproteins by Mass Spectrometry after On-Plate Phosphopeptide Enrichment Using Polymer-oxotitanium Films, Journal of Proteomic Research, 2010, 9, 3005-3015. DOI: 10.1021/pr901200m

    Identification of p65-Associated Phosphoproteins by Mass Spectrometry after On-Plate Phosphopeptide Enrichment Using Polymer-oxotitanium Films

  38. Hupp, Christopher D.; Tepe, Jetze J. 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride-Mediated Oxazole Rearrangement: Gaining Access to a Unique Marine Alkaloid Scaffold, Journal of Organic Chemistry, 2009, 74, 3406-3413. DOI: 10.1021/jo900264p
  1. Frawley Cass, Samantha M.; Reid, Gavin E.; Tepe, Jetze J. Synthesis of diazo ketone solid supports and their application towards the enrichment of phosphorylated peptides, Organic and Biomolecular Chemistry, 2009, 7, 3291-3299. DOI: 10.1039/b906577f

    Synthesis of diazo ketone solid supports and their application towards the enrichment of phosphorylated peptides,

  2. Hewlett, N. M.; Hupp, C. D.; Tepe, J. J. Reactivity of oxazol-5-(4H)-ones and their application toward natural product synthesis, Synthesis, 2009, 17, 2825-2839. DOI: 10.1055/s-0029-1216924
  3. Nguyen, T. N. T.; Tepe, Jetze J. Preparation of hymenialdisine, analogs and their evaluation as kinase inhibitors, Current Medicinal Chemistry, 2009, 16, 3122-3143. DOI: 10.2174/092986709788803015
  4. Tepe, Jetze J. Natural Product Inspired Small Molecular Scaffolds in Anticancer Therapy, Current Bioactive Compounds, 2009, 5, 1. DOI: 10.2174/157340709787580883
  5. Kahlon, Daljinder K.; Lansdell, Theresa A.; Fisk, Jason S.; Tepe, Jetze J. Structural activity relationship of functionalized trans-imidazolines as potent inhibitors of interleukin-6 production, Bioorganic & Medicinal Chemistry, 2009, 17, 3093-3103. DOI: 10.1016/j.bmc.2009.03.002

    Structural activity relationship of functionalized trans-imidazolines as potent inhibitors of interleukin-6 production

  6. Mosey, Robert A.; Tepe, Jetze J. New Synthetic Route to Access (±) Salinosporamide A via an Oxazolone Mediated Ene-type reaction, Tetrahedron Letters, 2009, 50, 295-297. DOI: 10.1016/j.tetlet.2008.10.154

    New Synthetic Route to Access (±) Salinosporamide A via an Oxazolone Mediated Ene-type reaction

  7. Kahlon, Daljinder K.; Lansdell, Theresa A.; Fisk, Jason S.; Hupp, Christopher D.; Friebe, Timothy L.; Hovde, Stacy; Jones, A. Daniel; Dyer, Richard D.; Henry, R. William; Tepe, Jetze J. Nuclear Factor-κB Mediated Inhibition of Cytokine Production by Imidazoline Scaffolds, Journal of Medicinal Chemistry, 2009, 52, 1302-1309. PMID: 19220017 DOI: 10.1021/jm8013162
    1. Article highlighted in: Science-Business eXchange 2009, 2, 18.

    Nuclear Factor-κB Mediated Inhibition of Cytokine Production by Imidazoline Scaffolds

  8. Hupp, Christopher D.; Tepe, Jetze J., Total synthesis of a marine alkaloid from the Tunicate Dendrodoa grossularia, Organic Letters, 2008, 10, 3737-3739. PMID: 18680306 DOI: 10.1021/ol801375k

    Total synthesis of a marine alkaloid from the Tunicate Dendrodoa grossularia

  9. Mosey, Robert A.; Tepe, Jetze J. Stereocontrolled synthesis of quaternary substituted amino acids using oxazolones, Tetrahedron Asymmetry, 2008, 19, 2755-2762. DOI: 10.1016/j.tetasy.2008.11.033

    Stereocontrolled synthesis of quaternary substituted amino acids using oxazolones

  10. Mosey, Robert A.; Fisk, Jason S.; Friebe, Timothy L.; Tepe, Jetze J. Synthesis of tert-Alkyl Amino Hydroxy Carboxylic Esters via an Intermolecular Ene-type Reaction of Oxazolones and Enol Ethers, Organic Letters, 2008, 10, 825-828. PMID: 18232699 DOI: 10.1021/ol702941f

    Synthesis of tert-Alkyl Amino Hydroxy Carboxylic Esters via an Intermolecular Ene-type Reaction of Oxazolones and Enol Ethers

  11. Palumbo, Amanda M.; Tepe, Jetze J.; Reid, Gavin E. Mechanistic Insights into the Multistage Gas-Phase Fragmentation Behavior of Phosphoserine- and Phosphothreonine-Containing Peptides, Journal of Proteomic Research, 2008, 7, 771-779. PMID: 18181561 DOI: 10.1021/pr0705136

    Mechanistic Insights into the Multistage Gas-Phase Fragmentation Behavior of Phosphoserine- and Phosphothreonine-Containing Peptides

  12. Fisk, Jason S.; Tepe, Jetze J. Intermolecular Ene Reactions Utilizing Oxazolones and Enol Ethers, Journal of the American Chemical Society, 2007, 129, 3058-3059. PMID: 17326632 DOI: 10.1021/ja0627904

    Intermolecular Ene Reactions Utilizing Oxazolones and Enol Ethers

  13. Fisk, Jason S.; Mosey, Robert A.; Tepe, Jetze J. The Diverse Chemistry of Azlactones, Chemistry Society Reviews, 2007, 36, 1432-1440. PMID: 17660876 DOI: 10.1039/b511113g

    The Diverse Chemistry of Azlactones

  14. Sharma, Vasudha; Hupp, Christopher D.; Tepe, Jetze J. Enhancement of Chemotherapeutic Efficacy by Small Molecule Inhibition of NF-kB and Checkpoint Kinases, Current Medicinal Chemistry, 2007, 14, 1061-1074. PMID: 17456020 DOI: 10.2174/092986707780362844
  15. Sharma, Vasudha; Peddibhotla, Satyamaheshwar; Tepe, Jetze J. Sensitization of Cancer Cells to DNA Damaging Agents by Imidazolines, Journal of the American Chemical Society,  2006, 128, 9137-9143. PMID: 16834387 DOI: 10.1021/ja060273f

    Sensitization of Cancer Cells to DNA Damaging Agents by Imidazolines

  16. Sharma, Vasudha; Tepe, Jetze J. Diastereochemical Diversity of Imidazoline Scaffolds via Substrate Controlled TMSCl Mediated Cycloaddition of Azlactones, Organic Letters, 2005, 7, 5091-5094. PMID: 16235965 DOI: 10.1021/ol052118w

    Diastereochemical Diversity of Imidazoline Scaffolds via Substrate Controlled TMSCl Mediated Cycloaddition of Azlactones

  17. Keni, Manasi; Tepe, Jetze J. One-pot Friedel-Crafts/Robinson-Gabriel Synthesis of Oxazoles Using Oxazolone Templates, Journal of Organic Chemistry, 2005, 70, 4211-4213. PMID: 15876123 DOI: 10.1021/jo0501590

    ne-pot Friedel-Crafts/Robinson-Gabriel Synthesis of Oxazoles Using Oxazolone Templates

  18. Sharma, Vasudha; Lansdell, Theresa A.; Peddibhotla, Satyamaheshwar; Tepe, Jetze J. Sensitization of Tumor Cells towards Chemotherapy: Enhancing the Efficacy of Camptothecin by Novel Imidazolines, Chemistry & Biology, 2004, 11, 1689-1699. PMID: 15610853 DOI: 10.1016/j.chembiol.2004.10.006
  19. Peddibhotla, Satyamaheshwar; Tepe, Jetze J. Stereoselective Synthesis of Highly Substituted D1-Pyrrolines: Exo Selective 1,3- Dipolar Cycloaddition Reactions with Azlactones, Journal of the American Chemical Society, 2004, 126, 12776-12777. PMID: 15469263 DOI: 10.1021/ja046149i

    Stereoselective Synthesis of Highly Substituted D1-Pyrrolines: Exo Selective 1,3- Dipolar Cycloaddition Reactions with Azlactones

  20. Sharma, Vasudha; Tepe, Jetze J. Potent Inhibition of Checkpoint Kinase Activity by a Hymenialdisine-derived Indoloazepine, Bioorganic & Medicinal Chemistry Letters, 2004, 14, 4319-4321. PMID: 15261294 DOI: 10.1016/j.bmcl.2004.05.079

    Potent Inhibition of Checkpoint Kinase Activity by a Hymenialdisine-derived Indoloazepine

  21. Sharma, Vasudha; Lansdell, Theresa A.; Jin, Guangyi; Tepe, Jetze J. Inhibition of Cytokine Production by Hymenialdisine Derivatives, Journal of Medicinal Chemistry, 2004, 47, 3700-3703.  PMID: 15214798 DOI: 10.1021/jm040013d

     

    Inhibition of Cytokine Production by Hymenialdisine Derivatives

  22. Lansdell, Theresa A.; Tepe, Jetze J. Isolation of Phosphopeptides using Solid Phase Enrichment, Tetrahedron Letters, 2004, 45, 91-93. DOI: 10.1016/j.tetlet.2003.10.111

    Isolation of Phosphopeptides using Solid Phase Enrichment

  23. Peddibhotla, S.; Tepe, Jetze J. Multicomponent Synthesis of Highly Substituted Imidazolines via a Silicon Mediated 1,3-Dipolar Cycloaddition, Synthesis, 2003, 9, 1433-1440. DOI: 10.1055/s-2003-40196
  24. Peddibhotla, Satyamaheshwar; Cheng, Zigang; DellaPenna, Dean; Tepe, Jetze J. Efficient Two-step Synthesis of Methylphytylbenzoquinones: Precursor Intermediates in the Biosynthesis of Vitamin E. Tetrahedron Letters, 2003, 44, 237-239. DOI: 10.1016/S0040-4039(02)02564-9
  25. Anderson, Kevin W.; Tepe, Jetze J. Trifluorosulfonic Acid Catalyzed Friedel-Crafts Acylation of Aromatics with β-Lactams. Tetrahedron, 2002, 58, 8475-8481. DOI: 10.1016/S0040-4020(02)01026-8

    Trifluorosulfonic Acid Catalyzed Friedel-Crafts Acylation of Aromatics with β-Lactams

    irst Intermolecular Friedel-Crafts Acylations with β-Lactams

     

     

    PRIOR TO INDEPENDENT CAREE

     

  26. Peddibhotla, Satymaheshwar; Jayakumar, S.; Tepe, Jetze J. Highly Diastereoselective Multicomponent Synthesis of Unsymmetrical Imidazoline Scaffolds, Organic Letters, 2002, 4, 3533-3535. PMID: 12323062 DOI: 10.1021/ol026703y

     

    Highly Diastereoselective Multicomponent Synthesis of Unsymmetrical Imidazoline Scaffolds

  27. Anderson, Kevin W.; Tepe, Jetze J. First Intermolecular Friedel-Crafts Acylations with β-Lactams, Organic Letters, 2002, 4, 459-461. PMID: 11820904 DOI: 10.1021/ol010291w
  28. J.J. Tepe, C. Kosogof, and R.M. Williams. DNA Interstrand Cross-link Formation by Reductive Activation of Dehydropyrrolizidine Progenitors, Tetrahedron, 2002, 58, 3553-3559.
  29. L. Beckenbauer, J.J. Tepe, R. A. Eastman, P. Mixter, R. M. Williams and R. Reeves. Vascular Leak Syndrome and Drug Design: Insights from FR900482 and FK317, Chemistry & Biology, 2002, 9, 427-441.
  30. C. Kosogof, J. J. Tepe and R. M. Williams. DNA Cross-linking by a Phototriggered Pyrrolic Progenitor developed from Monocrotaline, Tetrahedron Letters, 2001, 42, 6641-6643.
  31. L. Beckenbauer, J. J. Tepe, J. Cullison, R. Reeves and R. M. Williams. FR900482 Class of Anti-Tumor Drugs Cross-links Oncoprotein HMG I/Y to DNA in vivo, Chemistry & Biology, 2000, 7, 805-812.
  32. J.J. Tepe and R.M. Williams. Reductive Activation of a Hydroxylamino Hemi-acetal Derivative of Dehydro -monocrotaline. DNA Cross-linking Studies, Angewandte Chemie International Edition, 1999, 38,3501-3503.
  33. J.J. Tepe and R. M. Williams, DNA Cross-linking of a Photoactivated Dehydro- monocrotaline Progenitor, Journal of the American Chemical Society, 1999, 224, 2450-2456.
  34. M.A. Labroli, T. L. Macdonald, and J. J. Tepe; DNA Topoisomerase II Inhibitors, In: Comprehensive Natural Products Chemistry, E.T. Kool, ed., Elsevier-North Holland, Amsterdam, The Netherlands, Chap. 19, 1997.
  35. J.S. Madalengoitia, J. J. Tepe, K. A. Werbovetz, E. K. Lehnert and T. L. Macdonald. Structure-Activity Relationship for DNA Topoisomerase II Induced DNA Cleavage by Azatoxin Analogs, Bioorganic & Medicinal Chemistry, 1997, 5, 1807-1815. [LINK]
  36. J.J. Tepe, J. S. Madalengoitia, K. Miller Slunt, K. W. Werbovetz, P. Grant Spoors and T. L. Macdonald. Inhibition of DNA Topoisomerase II by Aza-elliptitoxins Functionalyzed in the Variable Substituent Domain, Journal of Medicinal Chemistry, 1996, 39, 2188-2196.