Publications

1. Mehedi, Md Shafaat Al and Tepe, Jetze J.Recent Advances in the Synthesis of Imidazolines (2009-2020)", Adv. Synth. Catal. 2020, in press. DOI:10.1002/adsc.202000709.
2. Mehedi, Md Shafaat Al and Tepe, Jetze J. Sc(OTf)₃ mediated one pot synthesis of 2,3-disubstituted quinolines from anilines and epoxides, J. Org. Chem. 2020, 85, 6741-6746. DOI:10.1021/acs.joc.0c00803 

2.  Article highlighted in Synfacts 2020; 16(08): 0898. DOI: 10.1055/s-0040-1706834
3. Njomen, Evert; Lansdell, Theresa A.; Vanecek, Allison, Benham, V. ; Krieger-Burke, Teresa; Bernard, Matthew; Yang Ya-Ting; Alkharabsheh, Omar; Al-Janadi, Anas; Bailie, Marc; Taylor, Catherine; Lau, Sarah; Bernard, Jamie; Yuzbasiayan-Gurkan, V. and Tepe, Jetze J. 20S Proteasome enhancement targets the intrinsically disordered c-MYC and induces in vivo anti-tumor efficacy, 2020, submitted.
4. Jones, Corey and Tepe, Jetze J. Proteasome Activation to Combat Proteotoxicity, Molecules, 2019, 24, 2841. PMID 31387243  DOI: 10.3390/molecules24152841
   1. Special Issue: Proteasome Regulators: Activators and Inhibitors
5. Njomen, Evert and Tepe, Jetze J. Regulation of Autophagic Flux by the 20S proteasome. Cell, Chemical Biology, 2019, 26, 1283-1294. PMID31327703 DOI: 10.1016/j.chembiol.2019.07.002
6. Njomen, Evert and Tepe, Jetze J. Proteasome activation as a new therapeutic approach to target proteotoxic disorders, Journal of Medicinal Chemistry, 2019, 62, 6469-6481. PMID: 30839208. DOI: 10.1021/acs.jmedchem.9b00101
   1. Article recommended by F1000Prime

6. Mehedi, Md Shafaat Al and Tepe, Jetze J. Diastereoselective one-pot synthesis of oxazolines using sulfur ylides and acyl imines, Journal of Organic Chemistry, 2019, 84, 7219-7226. PMID: 31117573. DOI: 10.1021/acs.joc.9b00883

7. Giletto, Matthew B; Osmulski, Pawel A.; Jones, Corey L.; Gaczynska Marie E. and Tepe, Jetze J. Pipecolic esters as new templates for proteasome inhibition, Organic & Biomolecular Chemistry, 2019, 17, 2734-2746. PMID: 30778435. DOI: 10.1039/c9ob00122k
8. Gao, Shuang, Bethel, Travis K. Kakeshpour T.; Hubbell, Grace E., Jackson, James, E. and Tepe, Jetze J. Substrate Controlled Regioselective Bromination of 2-Aycl Pyrroles Using Tetrabutyl Ammonium Tribromide (TBABr₃), Journal of Organic Chemistry, 2018, 83, 9250-9255. PMID: 29969032. DOI: 10.1021/acs.joc.8b01251

9. Njomen, Evert; Osmulski, Pawel A.; Jones, Corey L; Lansdell, Theresa A. Gaczynska, Maria E. and Tepe, Jetze J. Small Molecule Modulation of Proteasome Assembly, Biochemistry 2018, 57,4214-4224. PMID: 29897236. DOI: 10.1021/acs.biochem.8b00579
   1. Article recommended by F1000Prime

10. Jones, Corey L.; Njomen, Evert; Sjogren B.; Dexheimer, Thomas S. and Tepe, Jetze J. Small molecule enhancement of 20S proteasome activity targets intrinsically disordered proteins, ACS Chemical Biology 2017, 15, 2240-2247. PMID: 28719185. DOI: 10.1021/acschembio.7b00489

11. McDaniel, Tanner J.; Lansdell, Theresa A.; Dissanayake, Amila A.; Azevedo, Lauren M.; Claes, Jacob; Odom, Aaron L. and Tepe, Jetze J. Substituted quinolines as noncovalent proteasome inhibitors, Bioorganic and Medicinal Chemistry, 2016, 24, 2441-2450. PMID: 27112450. DOI: 10.1016/j.bmc.2016.04.005

12. Zaib, Rahman S. and Tepe, Jetze J. A concise total synthesis of hymenialdisine, Tetrahedron Letters, 2015, 56, 3011-3013. DOI: 10.1016/j.tetlet.2014.10.022
    1. Article selected for: Special Issue dedicated to Prof. H. Wasserman.

13. Kuszpit, Michael R.; Giletto, Matthew B.; Jones, Corey L.; Bethel, Travis K. and Tepe, Jetze J. Hydroxyamination of olefins using Br-N-(CO₂Me)₂. Journal of Organic Chemistry, 2015, 80, 1440-1445. PMID: 25574949. DOI: 10.1021/jo502369d

14. Beck, Philipp; Lansdell, Theresa A.; Hewlett, Nicole M.; Tepe, Jetze J. and Groll, Michael. Indolo-phakellins as b5-specific noncovalent proteasome inhibitors, Angewandte Chemie International Edition, 2015, 54, 2830-2833. PMID: 25581903. DOI: 10.1002/anie.201410168
    1. Article highlighted by editors as: Hot Paper.
15. Basson, Marc D.; Zeng B; Downey C; Siriveluprabhakara S, Tepe, Jetze J. Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-b, Molecular Oncology, 2015, 9, 513-526. PMC: 4487881. DOI: 10.1016/j.molonc.2014.10.008
16. Hewlett, Nicole M. and Tepe, Jetze J. 2-Phenyl oxazolone, Electronic Encyclopedia of Reagents for Organic Synthesis, 2014, 1-3. DOI: 10.1002/047084289X.rn01743
17. Azevedo, Lauren M.; Lansdell, Theresa A.; Ludwig, Jacob R.; Mosey, R. Adam; Woloch, Daljinder K.; Cogan, Dillon P.; Patten, Gregory P.; Kuszpit, Michael R.; Fisk, Jason S. and Tepe, Jetze J. Inhibition of the human proteasome by imidazoline scaffolds, Journal of Medicinal Chemistry, 2013, 56, 5974-5978. PMC: 3844044. DOI: 10.1021/jm400235r
    1. Article Highlighted in Science Business Exchange SciBX 6(28), July 25, 2013

18. Lansdell, Theresa A.; Hurchla, Michelle A.; Xiang, J.; Hovde, S.; Weilbaecher, Katherine N.; Henry, R. William; Tepe, Jetze J. Noncompetitive modulation of the proteasome by imidazoline scaffolds overcomes bortezomib resistance and delays MM tumor growth in vivo, ACS Chemical Biology, 2013, 8, 578-587. PMC: 3600058. DOI: 10.1021/cb300568r
    1. Article Highlighted: ACS Chemical Biology editors highlight article from Volume 8, Issue 3 and speak with author Jetze Tepe on itunes podcast, March 2013.
    2. Article recommended by F1000Prime

19. Nguyen, Thu N.T.; Saleem, Rahman S. Z.; Luderer, Micah, J.; Tepe, Jetze J. Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors, ACS Chemical Biology, 2012, 7, 172-184. PMID: 22004065. DOI: 10.1021/cb200320c

20. Lansdell, Theresa A.; O'Reilly, Sandra; Woolliscroft, Tracey; Azevedo, Lauren M.; Kahlon, Daljinder K.; Hovde, Stacy; McCormick, J. Justin; Henry, R. William; Cornicelli, Joseph A.; Tepe, Jetze J. Non-competitive inhibition of the human proteasome attenuates collagen-induced arthritis, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 4816-4819.  PMID: 22682057. DOI: 10.1016/j.bmcl.2012.05.056

21. Lansdell, Theresa A.; Hewlett, Nicole M.; Skoumbourdis, Amanda P.; Fodor, Matthew D.; Seiple, Ian B.; Su, Shun; Baran, Phil. S.; Feldman, Ken S.; Tepe, Jetze J. Palau’amine and Related Oroidin-alkaloids Dibromophakellin and Dibromophakellstatin Inhibit the Human 20S Proteasome. Journal of Natural Products, 2012, 75, 980-985.  PMC: 3367325. DOI: 10.1021/np300231f
    1. Article recommended by F1000Prime, 17 Jul 2018; F1000Prime.com/717748071

22. Saleem, Rahman Shah Zaib; Lansdell, Theresa A.; Tepe, Jetze J. Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors, Bioorganic & Medicinal Chemistry, 2012, 20, 1475-1481. PMID: 20481587. DOI: 10.1016/j.bmc.2011.12.054

23. Hewlett, Nicole M.; Tepe, Jetze J. Total synthesis of the natural product (±)-dibromophakellin and analogues, Organic Letters, 2011, 13, 4550-4553. PMC: 3162990. DOI: 10.1021/ol201741r

24. Nguyen, T. N. T.; Tepe, Jetze J. Checkpoint kinase inhibitors. Current Medicinal Chemistry, 2011, 18, 4368-4374. DOI: 10.2174/092986711797200390
25. Qu, Ke; Fisk, Jason S.; Tepe, Jetze J. Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolines, Tetrahedron Letters, 2011, 52, 4840-4842. PMC: 3157035. DOI: 10.1016/j.tetlet.2011.07.022

26. Frawley Cass, Samantha M.; Tepe, Jetze J.  Identification of phosphoproteins and their impact as biomarkers in cancer therapeutics,   Current Signal Transduction Therapy, 2011, 6, 113-140. DOI: 10.2174/157436211794109389
27. Kuszpit, Michael R.; Wulff, William D.; Tepe, Jetze J. One-Pot Synthesis of 2-Imidazolines via the Ring Expansion of Imidoyl Chlorides with Aziridines,  Journal of Organic Chemistry, 2011, 76, 2913-2919. PMC: 3074022. DOI: 10.1021/jo200101q

28. Saleem, Rahman Shah Zaib; Tepe, Jetze J. Synthesis of 1,2,4-triazolines and triazoles utilizing oxazolones,  Journal of Organic Chemistry, 2010, 75, 4330-4332. DOI: 10.1021/jo100716m
    1. Article highlighted in Synfacts 2010, 0997.

29. Tepe, Jetze J. Recent advances in cycloaddition reactions in natural product synthesis, Current Organic Synthesis, 2010,7, 311. DOI: 10.2174/157017910791414481
30. Wang, Wei-Han; Palumbo, Amanda M.; Tan, Yu-Jing; Reid, Gavin E.; Tepe, Jetze J.; Bruening, Merlin L. Identification of p65-Associated Phosphoproteins by Mass Spectrometry after On-Plate Phosphopeptide Enrichment Using Polymer-oxotitanium Films, Journal of Proteomic Research, 2010, 9, 3005-3015. DOI: 10.1021/pr901200m

31. Hupp, Christopher D.; Tepe, Jetze J. 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride-Mediated Oxazole Rearrangement: Gaining Access to a Unique Marine Alkaloid Scaffold, Journal of Organic Chemistry, 2009, 74, 3406-3413. DOI: 10.1021/jo900264p

32. Frawley Cass, Samantha M.; Reid, Gavin E.; Tepe, Jetze J. Synthesis of diazo ketone solid supports and their application towards the enrichment of phosphorylated peptides, Organic and Biomolecular Chemistry, 2009, 7, 3291-3299. DOI: 10.1039/b906577f

33. Hewlett, N. M.; Hupp, C. D.; Tepe, J. J. Reactivity of oxazol-5-(4H)-ones and their application toward natural product synthesis, Synthesis, 2009, 17, 2825-2839. DOI: 10.1055/s-0029-1216924
34. Nguyen, T. N. T.; Tepe, Jetze J. Preparation of hymenialdisine, analogs and their evaluation as kinase inhibitors, Current Medicinal Chemistry, 2009, 16, 3122-3143. DOI: 10.2174/092986709788803015
35. Tepe, Jetze J. Natural Product Inspired Small Molecular Scaffolds in Anticancer Therapy, Current Bioactive Compounds, 2009, 5, 1. DOI: 10.2174/157340709787580883
36. Kahlon, Daljinder K.; Lansdell, Theresa A.; Fisk, Jason S.; Tepe, Jetze J. Structural activity relationship of functionalized trans-imidazolines as potent inhibitors of interleukin-6 production, Bioorganic & Medicinal Chemistry, 2009, 17, 3093-3103. DOI: 10.1016/j.bmc.2009.03.002

37. Mosey, Robert A.; Tepe, Jetze J. New Synthetic Route to Access (±) Salinosporamide A via an Oxazolone Mediated Ene-type reaction, Tetrahedron Letters, 2009, 50, 295-297. DOI: 10.1016/j.tetlet.2008.10.154

38. Kahlon, Daljinder K.; Lansdell, Theresa A.; Fisk, Jason S.; Hupp, Christopher D.; Friebe, Timothy L.; Hovde, Stacy; Jones, A. Daniel; Dyer, Richard D.; Henry, R. William; Tepe, Jetze J. Nuclear Factor-κB Mediated Inhibition of Cytokine Production by Imidazoline Scaffolds, Journal of Medicinal Chemistry, 2009, 52, 1302-1309. PMID: 19220017 DOI: 10.1021/jm8013162
    1. Article highlighted in: Science-Business eXchange 2009, 2, 18.

39. Hupp, Christopher D.; Tepe, Jetze J., Total synthesis of a marine alkaloid from the Tunicate Dendrodoa grossularia, Organic Letters, 2008, 10, 3737-3739. PMID: 18680306 DOI: 10.1021/ol801375k

40. Mosey, Robert A.; Tepe, Jetze J. Stereocontrolled synthesis of quaternary substituted amino acids using oxazolones, Tetrahedron Asymmetry, 2008, 19, 2755-2762. DOI: 10.1016/j.tetasy.2008.11.033

41. Mosey, Robert A.; Fisk, Jason S.; Friebe, Timothy L.; Tepe, Jetze J. Synthesis of tert-Alkyl Amino Hydroxy Carboxylic Esters via an Intermolecular Ene-type Reaction of Oxazolones and Enol Ethers, Organic Letters, 2008, 10, 825-828. PMID: 18232699 DOI: 10.1021/ol702941f

42. Palumbo, Amanda M.; Tepe, Jetze J.; Reid, Gavin E. Mechanistic Insights into the Multistage Gas-Phase Fragmentation Behavior of Phosphoserine- and Phosphothreonine-Containing Peptides, Journal of Proteomic Research, 2008, 7, 771-779. PMID: 18181561 DOI: 10.1021/pr0705136

43. Fisk, Jason S.; Tepe, Jetze J. Intermolecular Ene Reactions Utilizing Oxazolones and Enol Ethers, Journal of the American Chemical Society, 2007, 129, 3058-3059. PMID: 17326632 DOI: 10.1021/ja0627904

44. Fisk, Jason S.; Mosey, Robert A.; Tepe, Jetze J. The Diverse Chemistry of Azlactones, Chemistry Society Reviews, 2007, 36, 1432-1440. PMID: 17660876 DOI: 10.1039/b511113g

45. Sharma, Vasudha; Hupp, Christopher D.; Tepe, Jetze J. Enhancement of Chemotherapeutic Efficacy by Small Molecule Inhibition of NF-kB and Checkpoint Kinases, Current Medicinal Chemistry, 2007, 14, 1061-1074. PMID: 17456020 DOI: 10.2174/092986707780362844
46. Sharma, Vasudha; Peddibhotla, Satyamaheshwar; Tepe, Jetze J. Sensitization of Cancer Cells to DNA Damaging Agents by Imidazolines, Journal of the American Chemical Society,  2006, 128, 9137-9143. PMID: 16834387 DOI: 10.1021/ja060273f

 

47. Sharma, Vasudha; Tepe, Jetze J. Diastereochemical Diversity of Imidazoline Scaffolds via Substrate Controlled TMSCl Mediated Cycloaddition of Azlactones, Organic Letters, 2005, 7, 5091-5094. PMID: 16235965 DOI: 10.1021/ol052118w

48. Keni, Manasi; Tepe, Jetze J. One-pot Friedel-Crafts/Robinson-Gabriel Synthesis of Oxazoles Using Oxazolone Templates, Journal of Organic Chemistry, 2005, 70, 4211-4213. PMID: 15876123 DOI: 10.1021/jo0501590

49. Sharma, Vasudha; Lansdell, Theresa A.; Peddibhotla, Satyamaheshwar; Tepe, Jetze J. Sensitization of Tumor Cells towards Chemotherapy: Enhancing the Efficacy of Camptothecin by Novel Imidazolines, Chemistry & Biology, 2004, 11, 1689-1699. PMID: 15610853 DOI: 10.1016/j.chembiol.2004.10.006
50. Peddibhotla, Satyamaheshwar; Tepe, Jetze J. Stereoselective Synthesis of Highly Substituted D¹-Pyrrolines: Exo Selective 1,3- Dipolar Cycloaddition Reactions with Azlactones, Journal of the American Chemical Society, 2004, 126, 12776-12777. PMID: 15469263 DOI: 10.1021/ja046149i

51. Sharma, Vasudha; Tepe, Jetze J. Potent Inhibition of Checkpoint Kinase Activity by a Hymenialdisine-derived Indoloazepine, Bioorganic & Medicinal Chemistry Letters, 2004, 14, 4319-4321. PMID: 15261294 DOI: 10.1016/j.bmcl.2004.05.079

52. Sharma, Vasudha; Lansdell, Theresa A.; Jin, Guangyi; Tepe, Jetze J. Inhibition of Cytokine Production by Hymenialdisine Derivatives, Journal of Medicinal Chemistry, 2004, 47, 3700-3703.  PMID: 15214798 DOI: 10.1021/jm040013d

 

53. Lansdell, Theresa A.; Tepe, Jetze J. Isolation of Phosphopeptides using Solid Phase Enrichment, Tetrahedron Letters, 2004, 45, 91-93. DOI: 10.1016/j.tetlet.2003.10.111

54. Peddibhotla, S.; Tepe, Jetze J. Multicomponent Synthesis of Highly Substituted Imidazolines via a Silicon Mediated 1,3-Dipolar Cycloaddition, Synthesis, 2003, 9, 1433-1440. DOI: 10.1055/s-2003-40196
55. Peddibhotla, Satyamaheshwar; Cheng, Zigang; DellaPenna, Dean; Tepe, Jetze J. Efficient Two-step Synthesis of Methylphytylbenzoquinones: Precursor Intermediates in the Biosynthesis of Vitamin E. Tetrahedron Letters, 2003, 44, 237-239. DOI: 10.1016/S0040-4039(02)02564-9
56. Anderson, Kevin W.; Tepe, Jetze J. Trifluorosulfonic Acid Catalyzed Friedel-Crafts Acylation of Aromatics with β-Lactams. Tetrahedron, 2002, 58, 8475-8481. DOI: 10.1016/S0040-4020(02)01026-8

57. Peddibhotla, Satymaheshwar; Jayakumar, S.; Tepe, Jetze J. Highly Diastereoselective Multicomponent Synthesis of Unsymmetrical Imidazoline Scaffolds, Organic Letters, 2002, 4, 3533-3535. PMID: 12323062 DOI: 10.1021/ol026703y

 

58. Anderson, Kevin W.; Tepe, Jetze J. First Intermolecular Friedel-Crafts Acylations with β-Lactams, Organic Letters, 2002, 4, 459-461. PMID: 11820904 DOI: 10.1021/ol010291w

 

 

PRIOR TO INDEPENDENT CAREE

59. J.J. Tepe, C. Kosogof, and R.M. Williams. DNA Interstrand Cross-link Formation by Reductive Activation of Dehydropyrrolizidine Progenitors, Tetrahedron, 2002, 58, 3553-3559.
60. L. Beckenbauer, J.J. Tepe, R. A. Eastman, P. Mixter, R. M. Williams and R. Reeves. Vascular Leak Syndrome and Drug Design: Insights from FR900482 and FK317, Chemistry & Biology, 2002, 9, 427-441.
61. C. Kosogof, J. J. Tepe and R. M. Williams. DNA Cross-linking by a Phototriggered Pyrrolic Progenitor developed from Monocrotaline, Tetrahedron Letters, 2001, 42, 6641-6643.
62. L. Beckenbauer, J. J. Tepe, J. Cullison, R. Reeves and R. M. Williams. FR900482 Class of Anti-Tumor Drugs Cross-links Oncoprotein HMG I/Y to DNA in vivo, Chemistry & Biology, 2000, 7, 805-812.
63. J.J. Tepe and R.M. Williams. Reductive Activation of a Hydroxylamino Hemi-acetal Derivative of Dehydro -monocrotaline. DNA Cross-linking Studies, Angewandte Chemie International Edition, 1999, 38,3501-3503.
64. J.J. Tepe and R. M. Williams, DNA Cross-linking of a Photoactivated Dehydro- monocrotaline Progenitor, Journal of the American Chemical Society, 1999, 224, 2450-2456.
65. M.A. Labroli, T. L. Macdonald, and J. J. Tepe; DNA Topoisomerase II Inhibitors, In: Comprehensive Natural Products Chemistry, E.T. Kool, ed., Elsevier-North Holland, Amsterdam, The Netherlands, Chap. 19, 1997.
66. J.S. Madalengoitia, J. J. Tepe, K. A. Werbovetz, E. K. Lehnert and T. L. Macdonald. Structure-Activity Relationship for DNA Topoisomerase II Induced DNA Cleavage by Azatoxin Analogs, Bioorganic & Medicinal Chemistry, 1997, 5, 1807-1815. [LINK]
67. J.J. Tepe, J. S. Madalengoitia, K. Miller Slunt, K. W. Werbovetz, P. Grant Spoors and T. L. Macdonald. Inhibition of DNA Topoisomerase II by Aza-elliptitoxins Functionalyzed in the Variable Substituent Domain, Journal of Medicinal Chemistry, 1996, 39, 2188-2196.