Publications

  1. Mehedi, Md Shafaat Al and Tepe, Jetze J.Recent Advances in the Synthesis of Imidazolines (2009-2020)", Adv. Synth. Catal. 2020, in press. DOI:10.1002/adsc.202000709.
  2. Mehedi, Md Shafaat Al and Tepe, Jetze J. Sc(OTf)3 mediated one pot synthesis of 2,3-disubstituted quinolines from anilines and epoxides, J. Org. Chem. 2020, 85, 6741-6746. DOI:10.1021/acs.joc.0c00803 

Sc(OTf)3 mediated one pot synthesis of 2,3-disubstituted quinolines from anilines and epoxides

  1.  Article highlighted in Synfacts 2020; 16(08): 0898. DOI: 10.1055/s-0040-1706834
  2. Njomen, Evert; Lansdell, Theresa A.; Vanecek, Allison, Benham, V. ; Krieger-Burke, Teresa; Bernard, Matthew; Yang Ya-Ting; Alkharabsheh, Omar; Al-Janadi, Anas; Bailie, Marc; Taylor, Catherine; Lau, Sarah; Bernard, Jamie; Yuzbasiayan-Gurkan, V. and Tepe, Jetze J. 20S Proteasome enhancement targets the intrinsically disordered c-MYC and induces in vivo anti-tumor efficacy, 2020, submitted.
  3. Jones, Corey and Tepe, Jetze J. Proteasome Activation to Combat ProteotoxicityMolecules201924, 2841. PMID 31387243  DOI: 10.3390/molecules24152841
    1. Special Issue: Proteasome Regulators: Activators and Inhibitors
  4. Njomen, Evert and Tepe, Jetze J. Regulation of Autophagic Flux by the 20S proteasomeCell, Chemical Biology201926, 1283-1294. PMID31327703 DOI: 10.1016/j.chembiol.2019.07.002
  5. Njomen, Evert and Tepe, Jetze J. Proteasome activation as a new therapeutic approach to target proteotoxic disordersJournal of Medicinal Chemistry201962, 6469-6481. PMID: 30839208. DOI: 10.1021/acs.jmedchem.9b00101
    1. Article recommended by F1000Prime

Proteasome activation as a new therapeutic approach to target proteotoxic disorders

  1. Mehedi, Md Shafaat Al and Tepe, Jetze J. Diastereoselective one-pot synthesis of oxazolines using sulfur ylides and acyl iminesJournal of Organic Chemistry201984, 7219-7226. PMID: 31117573. DOI: 10.1021/acs.joc.9b00883

Diastereoselective one-pot synthesis of oxazolines using sulfur ylides and acyl imines

  1. Giletto, Matthew B; Osmulski, Pawel A.; Jones, Corey L.; Gaczynska Marie E. and Tepe, Jetze J. Pipecolic esters as new templates for proteasome inhibitionOrganic & Biomolecular Chemistry201917, 2734-2746. PMID: 30778435. DOI: 10.1039/c9ob00122k
  2. Gao, Shuang, Bethel, Travis K. Kakeshpour T.; Hubbell, Grace E., Jackson, James, E. and Tepe, Jetze J. Substrate Controlled Regioselective Bromination of 2-Aycl Pyrroles Using Tetrabutyl Ammonium Tribromide (TBABr3)Journal of Organic Chemistry201883, 9250-9255. PMID: 29969032. DOI: 10.1021/acs.joc.8b01251

Substrate Controlled Regioselective Bromination of 2-Aycl Pyrroles Using Tetrabutyl Ammonium Tribromide (TBABr3)

  1. Njomen, Evert; Osmulski, Pawel A.; Jones, Corey L; Lansdell, Theresa A. Gaczynska, Maria E. and Tepe, Jetze J. Small Molecule Modulation of Proteasome AssemblyBiochemistry 2018, 57,4214-4224. PMID: 29897236. DOI: 10.1021/acs.biochem.8b00579
    1. Article recommended by F1000Prime

Small Molecule Modulation of Proteasome Assembly

  1. Jones, Corey L.; Njomen, Evert; Sjogren B.; Dexheimer, Thomas S. and Tepe, Jetze J. Small molecule enhancement of 20S proteasome activity targets intrinsically disordered proteinsACS Chemical Biology 201715, 2240-2247. PMID: 28719185. DOI: 10.1021/acschembio.7b00489

Small molecule enhancement of 20S proteasome activity targets intrinsically disordered proteins

  1. McDaniel, Tanner J.; Lansdell, Theresa A.; Dissanayake, Amila A.; Azevedo, Lauren M.; Claes, Jacob; Odom, Aaron L. and Tepe, Jetze J. Substituted quinolines as noncovalent proteasome inhibitors, Bioorganic and Medicinal Chemistry201624, 2441-2450. PMID: 27112450. DOI: 10.1016/j.bmc.2016.04.005

 Substituted quinolines as noncovalent proteasome inhibitor

  1. Zaib, Rahman S. and Tepe, Jetze J. A concise total synthesis of hymenialdisineTetrahedron Letters2015, 56, 3011-3013. DOI: 10.1016/j.tetlet.2014.10.022
    1. Article selected for: Special Issue dedicated to Prof. H. Wasserman.

A concise total synthesis of hymenialdisine

  1. Kuszpit, Michael R.; Giletto, Matthew B.; Jones, Corey L.; Bethel, Travis K. and Tepe, Jetze J. Hydroxyamination of olefins using Br-N-(CO2Me)2Journal of Organic Chemistry, 2015, 80, 1440-1445. PMID: 25574949. DOI: 10.1021/jo502369d

Hydroxyamination of olefins using Br-N-(CO2Me)2

  1. Beck, Philipp; Lansdell, Theresa A.; Hewlett, Nicole M.; Tepe, Jetze J. and Groll, Michael. Indolo-phakellins as b5-specific noncovalent proteasome inhibitorsAngewandte Chemie International Edition, 201554, 2830-2833. PMID: 25581903. DOI: 10.1002/anie.201410168
    1. Article highlighted by editors as: Hot Paper.
  2. Basson, Marc D.; Zeng B; Downey C; Siriveluprabhakara S, Tepe, Jetze J. Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-bMolecular Oncology20159, 513-526. PMC: 4487881. DOI: 10.1016/j.molonc.2014.10.008
  3. Hewlett, Nicole M. and Tepe, Jetze J. 2-Phenyl oxazoloneElectronic Encyclopedia of Reagents for Organic Synthesis, 2014, 1-3. DOI: 10.1002/047084289X.rn01743
  4. Azevedo, Lauren M.; Lansdell, Theresa A.; Ludwig, Jacob R.; Mosey, R. Adam; Woloch, Daljinder K.; Cogan, Dillon P.; Patten, Gregory P.; Kuszpit, Michael R.; Fisk, Jason S. and Tepe, Jetze J. Inhibition of the human proteasome by imidazoline scaffoldsJournal of Medicinal Chemistry201356, 5974-5978. PMC: 3844044. DOI: 10.1021/jm400235r
    1. Article Highlighted in Science Business Exchange SciBX 6(28), July 25, 2013

Inhibition of the human proteasome by imidazoline scaffolds

  1. Lansdell, Theresa A.; Hurchla, Michelle A.; Xiang, J.; Hovde, S.; Weilbaecher, Katherine N.; Henry, R. William; Tepe, Jetze J. Noncompetitive modulation of the proteasome by imidazoline scaffolds overcomes bortezomib resistance and delays MM tumor growth in vivoACS Chemical Biology, 20138, 578-587. PMC: 3600058. DOI: 10.1021/cb300568r
    1. Article Highlighted: ACS Chemical Biology editors highlight article from Volume 8, Issue 3 and speak with author Jetze Tepe on itunes podcast, March 2013.
    2. Article recommended by F1000Prime

Noncompetitive modulation of the proteasome by imidazoline scaffolds overcomes bortezomib resistance and delays MM tumor growth in vivo

  1. Nguyen, Thu N.T.; Saleem, Rahman S. Z.; Luderer, Micah, J.; Tepe, Jetze J. Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors, ACS Chemical Biology, 20127, 172-184. PMID: 22004065. DOI: 10.1021/cb200320c

Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors

  1. Lansdell, Theresa A.; O'Reilly, Sandra; Woolliscroft, Tracey; Azevedo, Lauren M.; Kahlon, Daljinder K.; Hovde, Stacy; McCormick, J. Justin; Henry, R. William; Cornicelli, Joseph A.; Tepe, Jetze J. Non-competitive inhibition of the human proteasome attenuates collagen-induced arthritisBioorganic & Medicinal Chemistry Letters, 201222, 4816-4819.  PMID: 22682057. DOI: 10.1016/j.bmcl.2012.05.056

Non-competitive inhibition of the human proteasome attenuates collagen-induced arthritis

  1. Lansdell, Theresa A.; Hewlett, Nicole M.; Skoumbourdis, Amanda P.; Fodor, Matthew D.; Seiple, Ian B.; Su, Shun; Baran, Phil. S.; Feldman, Ken S.; Tepe, Jetze J. Palau’amine and Related Oroidin-alkaloids Dibromophakellin and Dibromophakellstatin Inhibit the Human 20S ProteasomeJournal of Natural Products, 201275, 980-985.  PMC: 3367325. DOI: 10.1021/np300231f
    1. Article recommended by F1000Prime, 17 Jul 2018; F1000Prime.com/717748071

Palau’amine and Related Oroidin-alkaloids Dibromophakellin and Dibromophakellstatin Inhibit the Human 20S Proteasome

  1. Saleem, Rahman Shah Zaib; Lansdell, Theresa A.; Tepe, Jetze J. Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitorsBioorganic & Medicinal Chemistry, 201220, 1475-1481. PMID: 20481587. DOI: 10.1016/j.bmc.2011.12.054

Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors

  1. Hewlett, Nicole M.; Tepe, Jetze J. Total synthesis of the natural product (±)-dibromophakellin and analoguesOrganic Letters, 201113, 4550-4553. PMC: 3162990. DOI: 10.1021/ol201741r

Total synthesis of the natural product (±)-dibromophakellin and analogues

  1. Nguyen, T. N. T.; Tepe, Jetze J. Checkpoint kinase inhibitorsCurrent Medicinal Chemistry, 201118, 4368-4374. DOI: 10.2174/092986711797200390
  2. Qu, Ke; Fisk, Jason S.; Tepe, Jetze J. Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolinesTetrahedron Letters, 201152, 4840-4842. PMC: 3157035. DOI: 10.1016/j.tetlet.2011.07.022

Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolines

  1. Frawley Cass, Samantha M.; Tepe, Jetze J.  Identification of phosphoproteins and their impact as biomarkers in cancer therapeutics,   Current Signal Transduction Therapy, 20116, 113-140. DOI: 10.2174/157436211794109389
  2. Kuszpit, Michael R.; Wulff, William D.; Tepe, Jetze J. One-Pot Synthesis of 2-Imidazolines via the Ring Expansion of Imidoyl Chlorides with Aziridines,  Journal of Organic Chemistry, 201176, 2913-2919. PMC: 3074022. DOI: 10.1021/jo200101q

One-Pot Synthesis of 2-Imidazolines via the Ring Expansion of Imidoyl Chlorides with Aziridines

  1. Saleem, Rahman Shah Zaib; Tepe, Jetze J. Synthesis of 1,2,4-triazolines and triazoles utilizing oxazolones Journal of Organic Chemistry2010, 75, 4330-4332. DOI: 10.1021/jo100716m
    1. Article highlighted in Synfacts 2010, 0997.

Synthesis of 1,2,4-triazolines and triazoles utilizing oxazolones

  1. Tepe, Jetze J. Recent advances in cycloaddition reactions in natural product synthesisCurrent Organic Synthesis2010,7, 311. DOI10.2174/157017910791414481
  2. Wang, Wei-Han; Palumbo, Amanda M.; Tan, Yu-Jing; Reid, Gavin E.; Tepe, Jetze J.; Bruening, Merlin L. Identification of p65-Associated Phosphoproteins by Mass Spectrometry after On-Plate Phosphopeptide Enrichment Using Polymer-oxotitanium FilmsJournal of Proteomic Research20109, 3005-3015. DOI: 10.1021/pr901200m

Identification of p65-Associated Phosphoproteins by Mass Spectrometry after On-Plate Phosphopeptide Enrichment Using Polymer-oxotitanium Films

  1. Hupp, Christopher D.; Tepe, Jetze J. 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride-Mediated Oxazole Rearrangement: Gaining Access to a Unique Marine Alkaloid ScaffoldJournal of Organic Chemistry, 200974, 3406-3413. DOI: 10.1021/jo900264p

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride-Mediated Oxazole Rearrangement: Gaining Access to a Unique Marine Alkaloid Scaffold

  1. Frawley Cass, Samantha M.; Reid, Gavin E.; Tepe, Jetze J. Synthesis of diazo ketone solid supports and their application towards the enrichment of phosphorylated peptidesOrganic and Biomolecular Chemistry, 20097, 3291-3299. DOI: 10.1039/b906577f

Synthesis of diazo ketone solid supports and their application towards the enrichment of phosphorylated peptides,

  1. Hewlett, N. M.; Hupp, C. D.; Tepe, J. J. Reactivity of oxazol-5-(4H)-ones and their application toward natural product synthesisSynthesis200917, 2825-2839. DOI: 10.1055/s-0029-1216924
  2. Nguyen, T. N. T.; Tepe, Jetze J. Preparation of hymenialdisine, analogs and their evaluation as kinase inhibitorsCurrent Medicinal Chemistry, 200916, 3122-3143. DOI: 10.2174/092986709788803015
  3. Tepe, Jetze J. Natural Product Inspired Small Molecular Scaffolds in Anticancer TherapyCurrent Bioactive Compounds, 20095, 1. DOI: 10.2174/157340709787580883
  4. Kahlon, Daljinder K.; Lansdell, Theresa A.; Fisk, Jason S.; Tepe, Jetze J. Structural activity relationship of functionalized trans-imidazolines as potent inhibitors of interleukin-6 productionBioorganic & Medicinal Chemistry200917, 3093-3103. DOI: 10.1016/j.bmc.2009.03.002

Structural activity relationship of functionalized trans-imidazolines as potent inhibitors of interleukin-6 production

  1. Mosey, Robert A.; Tepe, Jetze J. New Synthetic Route to Access (±) Salinosporamide A via an Oxazolone Mediated Ene-type reaction, Tetrahedron Letters, 200950, 295-297. DOI: 10.1016/j.tetlet.2008.10.154

New Synthetic Route to Access (±) Salinosporamide A via an Oxazolone Mediated Ene-type reaction

  1. Kahlon, Daljinder K.; Lansdell, Theresa A.; Fisk, Jason S.; Hupp, Christopher D.; Friebe, Timothy L.; Hovde, Stacy; Jones, A. Daniel; Dyer, Richard D.; Henry, R. William; Tepe, Jetze J. Nuclear Factor-κB Mediated Inhibition of Cytokine Production by Imidazoline ScaffoldsJournal of Medicinal Chemistry, 200952, 1302-1309. PMID: 19220017 DOI: 10.1021/jm8013162
    1. Article highlighted in: Science-Business eXchange 20092, 18.

Nuclear Factor-κB Mediated Inhibition of Cytokine Production by Imidazoline Scaffolds

  1. Hupp, Christopher D.; Tepe, Jetze J., Total synthesis of a marine alkaloid from the Tunicate Dendrodoa grossulariaOrganic Letters, 200810, 3737-3739. PMID: 18680306 DOI: 10.1021/ol801375k

Total synthesis of a marine alkaloid from the Tunicate Dendrodoa grossularia

  1. Mosey, Robert A.; Tepe, Jetze J. Stereocontrolled synthesis of quaternary substituted amino acids using oxazolonesTetrahedron Asymmetry, 200819, 2755-2762. DOI: 10.1016/j.tetasy.2008.11.033

Stereocontrolled synthesis of quaternary substituted amino acids using oxazolones

  1. Mosey, Robert A.; Fisk, Jason S.; Friebe, Timothy L.; Tepe, Jetze J. Synthesis of tert-Alkyl Amino Hydroxy Carboxylic Esters via an Intermolecular Ene-type Reaction of Oxazolones and Enol EthersOrganic Letters, 200810, 825-828. PMID: 18232699 DOI: 10.1021/ol702941f

Synthesis of tert-Alkyl Amino Hydroxy Carboxylic Esters via an Intermolecular Ene-type Reaction of Oxazolones and Enol Ethers

  1. Palumbo, Amanda M.; Tepe, Jetze J.; Reid, Gavin E. Mechanistic Insights into the Multistage Gas-Phase Fragmentation Behavior of Phosphoserine- and Phosphothreonine-Containing PeptidesJournal of Proteomic Research, 20087, 771-779. PMID: 18181561 DOI: 10.1021/pr0705136

Mechanistic Insights into the Multistage Gas-Phase Fragmentation Behavior of Phosphoserine- and Phosphothreonine-Containing Peptides

  1. Fisk, Jason S.; Tepe, Jetze J. Intermolecular Ene Reactions Utilizing Oxazolones and Enol EthersJournal of the American Chemical Society, 2007129, 3058-3059. PMID: 17326632 DOI: 10.1021/ja0627904

Intermolecular Ene Reactions Utilizing Oxazolones and Enol Ethers

  1. Fisk, Jason S.; Mosey, Robert A.; Tepe, Jetze J. The Diverse Chemistry of AzlactonesChemistry Society Reviews, 200736, 1432-1440. PMID: 17660876 DOI: 10.1039/b511113g

The Diverse Chemistry of Azlactones

  1. Sharma, Vasudha; Hupp, Christopher D.; Tepe, Jetze J. Enhancement of Chemotherapeutic Efficacy by Small Molecule Inhibition of NF-kB and Checkpoint Kinases, Current Medicinal Chemistry, 200714, 1061-1074. PMID: 17456020 DOI: 10.2174/092986707780362844
  2. Sharma, Vasudha; Peddibhotla, Satyamaheshwar; Tepe, Jetze J. Sensitization of Cancer Cells to DNA Damaging Agents by ImidazolinesJournal of the American Chemical Society,  2006, 128, 9137-9143. PMID: 16834387 DOI: 10.1021/ja060273f

Sensitization of Cancer Cells to DNA Damaging Agents by Imidazolines

 

  1. Sharma, Vasudha; Tepe, Jetze J. Diastereochemical Diversity of Imidazoline Scaffolds via Substrate Controlled TMSCl Mediated Cycloaddition of AzlactonesOrganic Letters, 2005, 7, 5091-5094. PMID: 16235965 DOI: 10.1021/ol052118w

Diastereochemical Diversity of Imidazoline Scaffolds via Substrate Controlled TMSCl Mediated Cycloaddition of Azlactones

  1. Keni, Manasi; Tepe, Jetze J. One-pot Friedel-Crafts/Robinson-Gabriel Synthesis of Oxazoles Using Oxazolone TemplatesJournal of Organic Chemistry, 200570, 4211-4213. PMID: 15876123 DOI: 10.1021/jo0501590

ne-pot Friedel-Crafts/Robinson-Gabriel Synthesis of Oxazoles Using Oxazolone Templates

  1. Sharma, Vasudha; Lansdell, Theresa A.; Peddibhotla, Satyamaheshwar; Tepe, Jetze J. Sensitization of Tumor Cells towards Chemotherapy: Enhancing the Efficacy of Camptothecin by Novel Imidazolines, Chemistry & Biology, 200411, 1689-1699. PMID: 15610853 DOI: 10.1016/j.chembiol.2004.10.006
  2. Peddibhotla, Satyamaheshwar; Tepe, Jetze J. Stereoselective Synthesis of Highly Substituted D1-Pyrrolines: Exo Selective 1,3- Dipolar Cycloaddition Reactions with AzlactonesJournal of the American Chemical Society, 2004, 126, 12776-12777. PMID: 15469263 DOI: 10.1021/ja046149i

Stereoselective Synthesis of Highly Substituted D1-Pyrrolines: Exo Selective 1,3- Dipolar Cycloaddition Reactions with Azlactones

  1. Sharma, Vasudha; Tepe, Jetze J. Potent Inhibition of Checkpoint Kinase Activity by a Hymenialdisine-derived IndoloazepineBioorganic & Medicinal Chemistry Letters, 2004, 14, 4319-4321. PMID: 15261294 DOI: 10.1016/j.bmcl.2004.05.079

Potent Inhibition of Checkpoint Kinase Activity by a Hymenialdisine-derived Indoloazepine

  1. Sharma, Vasudha; Lansdell, Theresa A.; Jin, Guangyi; Tepe, Jetze J. Inhibition of Cytokine Production by Hymenialdisine Derivatives, Journal of Medicinal Chemistry, 200447, 3700-3703.  PMID: 15214798 DOI: 10.1021/jm040013d

 

Inhibition of Cytokine Production by Hymenialdisine Derivatives

  1. Lansdell, Theresa A.; Tepe, Jetze J. Isolation of Phosphopeptides using Solid Phase EnrichmentTetrahedron Letters, 200445, 91-93. DOI: 10.1016/j.tetlet.2003.10.111

Isolation of Phosphopeptides using Solid Phase Enrichment

  1. Peddibhotla, S.; Tepe, Jetze J. Multicomponent Synthesis of Highly Substituted Imidazolines via a Silicon Mediated 1,3-Dipolar CycloadditionSynthesis, 20039, 1433-1440. DOI: 10.1055/s-2003-40196
  2. Peddibhotla, Satyamaheshwar; Cheng, Zigang; DellaPenna, Dean; Tepe, Jetze J. Efficient Two-step Synthesis of Methylphytylbenzoquinones: Precursor Intermediates in the Biosynthesis of Vitamin ETetrahedron Letters, 2003, 44, 237-239. DOI: 10.1016/S0040-4039(02)02564-9
  3. Anderson, Kevin W.; Tepe, Jetze J. Trifluorosulfonic Acid Catalyzed Friedel-Crafts Acylation of Aromatics with β-LactamsTetrahedron200258, 8475-8481. DOI: 10.1016/S0040-4020(02)01026-8

Trifluorosulfonic Acid Catalyzed Friedel-Crafts Acylation of Aromatics with β-Lactams

  1. Peddibhotla, Satymaheshwar; Jayakumar, S.; Tepe, Jetze J. Highly Diastereoselective Multicomponent Synthesis of Unsymmetrical Imidazoline Scaffolds, Organic Letters, 20024, 3533-3535. PMID: 12323062 DOI: 10.1021/ol026703y

 

Highly Diastereoselective Multicomponent Synthesis of Unsymmetrical Imidazoline Scaffolds

  1. Anderson, Kevin W.; Tepe, Jetze J. First Intermolecular Friedel-Crafts Acylations with β-Lactams, Organic Letters, 20024, 459-461. PMID: 11820904 DOI: 10.1021/ol010291w

irst Intermolecular Friedel-Crafts Acylations with β-Lactams

 

 

PRIOR TO INDEPENDENT CAREE

  1. J.J. Tepe, C. Kosogof, and R.M. Williams. DNA Interstrand Cross-link Formation by Reductive Activation of Dehydropyrrolizidine Progenitors, Tetrahedron, 200258, 3553-3559.
  2. L. Beckenbauer, J.J. Tepe, R. A. Eastman, P. Mixter, R. M. Williams and R. Reeves. Vascular Leak Syndrome and Drug Design: Insights from FR900482 and FK317Chemistry & Biology, 20029, 427-441.
  3. C. Kosogof, J. J. Tepe and R. M. Williams. DNA Cross-linking by a Phototriggered Pyrrolic Progenitor developed from MonocrotalineTetrahedron Letters, 2001, 42, 6641-6643.
  4. L. Beckenbauer, J. J. Tepe, J. Cullison, R. Reeves and R. M. Williams. FR900482 Class of Anti-Tumor Drugs Cross-links Oncoprotein HMG I/Y to DNA in vivoChemistry & Biology, 20007, 805-812.
  5. J.J. Tepe and R.M. Williams. Reductive Activation of a Hydroxylamino Hemi-acetal Derivative of Dehydro -monocrotaline. DNA Cross-linking StudiesAngewandte Chemie International Edition199938,3501-3503.
  6. J.J. Tepe and R. M. Williams, DNA Cross-linking of a Photoactivated Dehydro- monocrotaline ProgenitorJournal of the American Chemical Society, 1999224, 2450-2456.
  7. M.A. Labroli, T. L. Macdonald, and J. J. Tepe; DNA Topoisomerase II Inhibitors, In: Comprehensive Natural Products Chemistry, E.T. Kool, ed., Elsevier-North Holland, Amsterdam, The Netherlands, Chap. 19, 1997.
  8. J.S. Madalengoitia, J. J. Tepe, K. A. Werbovetz, E. K. Lehnert and T. L. Macdonald. Structure-Activity Relationship for DNA Topoisomerase II Induced DNA Cleavage by Azatoxin Analogs, Bioorganic & Medicinal Chemistry, 19975, 1807-1815. [LINK]
  9. J.J. Tepe, J. S. Madalengoitia, K. Miller Slunt, K. W. Werbovetz, P. Grant Spoors and T. L. Macdonald. Inhibition of DNA Topoisomerase II by Aza-elliptitoxins Functionalyzed in the Variable Substituent DomainJournal of Medicinal Chemistry, 199639, 2188-2196.