Fiolek, Taylor J.; Keel, Katarina L. and Tepe, Jetze J. Fluspirilene analogs activate the 20S proteasome and overcome proteasome impairment by intrinsically disorder protein oligomers, 2021, submitted.
Fiolek, Taylor J.; Magyar, Christina L.; Wall, Tyler J.; Davies, Steven B.; Campbell, Molly V.; Savich Christopher J.; Tepe, Jetze J. and Mosey, R. Adam, Dihydroquinazolines enhance 20S proteasome activity and induce degradation of alpha-synuclein, an intrinsically disordered protein associated with neurodegeneration, Bioorganic and Medicinal Chemistry Letters, 2021, ahead of print. https://doi: 10.1016/j.bmcl.2021.127821
Hubbell, Grace E. and Tepe, Jetze J. Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors, RSC Chemical Biology2020,1, 305-332.
Keel, Katarina L. and Tepe, Jetze J. The preparation of (4H)-imidazol-4-ones and their application in the total synthesis of natural products, Organic Chemistry Frontiers2020, 7, 3284-3311. https://doi.org/10.1039/D0QO00764A
Mehedi, Md Shafaat Al and Tepe, Jetze J. Recent Advances in the Synthesis of Imidazolines (2009-2020)", Adv. Synth. Catal. 2020, 362, 4189-4225. https://doi:10.1002/adsc.202000709
Njomen, Evert; Lansdell, Theresa A.; Benham, Vanessa; Bernard, Matt P.; Yang, Ya-Ting; Schall, Peter Z.; Isaac, Daniel;Omar Alkharabsheh; Al-Janadi Anas; Giletto, Matthew B.; Ellsworth, Edmund; Taylor, Catherine; Tang, Terence; Lau, Sarah; Bailie, Marc, Bernard; Jamie J.; Yuzbasiyan-Gurkan,Vilma and Tepe, Jetze J., 20S proteasome enhancement targets c-MYC and induces in vivo anti-tumor efficacy, BioRxiv, 2020, https://doi.org/10.1101/2020.08.24.265470
Azevedo, Lauren M.; Lansdell, Theresa A.; Ludwig, Jacob R.; Mosey, R. Adam; Woloch, Daljinder K.; Cogan, Dillon P.; Patten, Gregory P.; Kuszpit, Michael R.; Fisk, Jason S. and Tepe, Jetze J. Inhibition of the human proteasome by imidazoline scaffolds, Journal of Medicinal Chemistry, 2013, 56, 5974-5978. PMC: 3844044. DOI: 10.1021/jm400235r
Article Highlighted in Science Business ExchangeSciBX 6(28), July 25, 2013
Article Highlighted: ACS Chemical Biology editors highlight article from Volume 8, Issue 3 and speak with author Jetze Tepe on itunes podcast, March 2013.
M.A. Labroli, T. L. Macdonald, and J. J. Tepe; DNA Topoisomerase II Inhibitors, In: Comprehensive Natural Products Chemistry, E.T. Kool, ed., Elsevier-North Holland, Amsterdam, The Netherlands, Chap. 19, 1997.